Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.5
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.9
Supplement Facts
Serving Size: 2 Veg Capsules
Serving Per Container: 60
Amount Per Serving
%DV
BioCell Collagen® (Hydrolyzed Chicken Sternal Cartilage Extract) providing
1 g (1,000 mg)
**
Hydrolyzed Type II Collagen
570 mg
**
Chondroitin Sulfate
190 mg
**
Hyaluronic Acid
95 mg
**
Top Medical Research Studies
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
8
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Read More
8
Hyaluronic acid effectiveness evaluated
We explored how hyaluronic acid (HA) injections affect knee osteoarthritis (OA) pain and function. This study involved 128 patients, comparing the impact of a single high-dose injection to triple low-dose injections over 12 months.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Interestingly, the triple low-dose injections demonstrated better results, improving pain and function more effectively than the single high-dose approach.
So, for those dealing with knee OA, multiple, lower dose HA injections might be the way to go for relief.
Read More
Most Useful Reviews
9
Notable improvements
6 people found this helpful
I recommended this for my mother whose knees pained her excessively, to the point of struggling to walk. Doctors suggested costly knee injections, yet many report them as ineffective. Instead, we opted for collagen, glucosamine, and chondroitin in courses, leading to noticeable improvements. We will continue this regimen.
Read More
9
Visible improvements
3 people found this helpful
I’m delighted with this super collagen. Despite its small size, it has impressive benefits, particularly
for my knee pain, which has subsided significantly. I noticed improvements in my health with regular use.
Read More
9
Significant improvement
3 people found this helpful
Effective! This is a great complex. My mum has finger joint issues and I have knee pain which causes crunching during fitness. We take it in courses for three months, and after three weeks, I felt noticeable improvement. By the end of the course, our issues seemed to vanish. Highly recommended!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.5
- All Researches
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
Read More
9
This study set out to determine if oral collagen supplements could help treat knee pain linked to osteoarthritis caused by ACL injury in rats.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
Read More
9
We explored the effectiveness of a treatment for knee osteoarthritis that combines oral duloxetine with an injection of hyaluronic acid and corticosteroid. Conducted at Beijing Tiantan Hospital, this study involved 150 patients who were randomly assigned to either the combined treatment or the injection alone.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
After 24 weeks, results showed that those receiving the combination experienced a significant reduction in pain and improvement in knee function. However, it’s important to note that this study only assessed effects over a short term, so longer follow-ups will be necessary to determine lasting benefits.
Read More
9
We explored the effectiveness of hyaluronic acid injections for managing knee pain in patients with hemophilic arthropathy. Research indicated that a significant portion of participants experienced pain relief, with 91% reporting improvement over six years, and 82% of those with knee arthropathy seeing similar results after seven years. While findings varied across studies, it suggests that these injections can be beneficial for several months and can be repeated every six to twelve months. However, the overall data is somewhat diverse and complex.
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9
We explored the impact of hyaluronic acid (HA) sheet transplantation on knee pain in a rat arthritis model. This study administered HA sheets to right knees of rats following induced arthritis while left knees underwent sham surgery.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
We observed significant pain relief and reduced inflammation in the knees treated with HA. Notably, these sheets decreased cartilage damage and fibrosis, offering hope for chronic knee pain management. However, the full extent of benefits needs further investigation in human subjects.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 35 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Notable improvements
6 people found this helpful
I recommended this for my mother whose knees pained her excessively, to the point of struggling to walk. Doctors suggested costly knee injections, yet many report them as ineffective. Instead, we opted for collagen, glucosamine, and chondroitin in courses, leading to noticeable improvements. We will continue this regimen.
Read More
9
Visible improvements
3 people found this helpful
I’m delighted with this super collagen. Despite its small size, it has impressive benefits, particularly
for my knee pain, which has subsided significantly. I noticed improvements in my health with regular use.
Read More
9
Significant improvement
3 people found this helpful
Effective! This is a great complex. My mum has finger joint issues and I have knee pain which causes crunching during fitness. We take it in courses for three months, and after three weeks, I felt noticeable improvement. By the end of the course, our issues seemed to vanish. Highly recommended!
Read More
9
Excellent for joints
2 people found this helpful
I took Collagen for my mother because of her knee. It is excellent and has an acceptable taste.
The benefits are remarkable.
Read More
9
Stopped knee crunching
2 people found this helpful
This product works effectively when combined with chondroprotectors and vitamins. I have found that my knees have stopped crunching and hurting since I started using it.
Read More
Frequently Asked Questions
9
Significant improvement
3 people found this helpful
Effective! This is a great complex. My mum has finger joint issues and I have knee pain which causes crunching during fitness. We take it in courses for three months, and after three weeks, I felt noticeable improvement. By the end of the course, our issues seemed to vanish. Highly recommended!
9
Significant pain relief
2 people found this helpful
Excellent collagen! My knees began to 'ache' much less frequently after two weeks. I take collagen in courses (30 days continuously) three times a year. If the pain is severe, I take it four times. This always helps!
9
Elderly parents improved
1 people found this helpful
I buy for my elderly parents (65-66 years old). They complained of knee pain, but after taking this collagen, they say they feel better and there is a noticeable effect. They now ask me to buy them more, taking it in courses for 2-3 months, twice a year.
9
Near symptom-free
1 people found this helpful
Having arthritis in my knee, I took these alongside daily long walks. After a year of consistent use,
I am almost symptom-free, which has vastly improved my quality of life.
7.5
Improved knee pain
1 people found this helpful
I have knee problems. Climbing stairs or doing squats causes pain. After reading about type 2 collagen, I decided to try it. I’ve been taking it for over a week and can already feel improvement. I hope it continues to get better.
9
Less pain noticed
1 people found this helpful
I drink this together with glucosamine, chondroitin, and vitamin C. The result is positive since my knees began to hurt much less! I will continue.
9
Stopped knee crunching
2 people found this helpful
This product works effectively when combined with chondroprotectors and vitamins. I have found that my knees have stopped crunching and hurting since I started using it.
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
8
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
8
Collagen aids osteoarthritis symptoms
We analyzed various randomized placebo-controlled trials to determine how collagen supplements impact knee pain from osteoarthritis.
The results show that collagen can effectively reduce overall OA symptoms, particularly stiffness, as reflected in improved scores on both the WOMAC index and the Visual Analog Scale.
However, improvements in pain and functional limitations were not significant. Overall, collagen appears beneficial for stiffness and the overall experience of knee pain.
The results show that collagen can effectively reduce overall OA symptoms, particularly stiffness, as reflected in improved scores on both the WOMAC index and the Visual Analog Scale.
However, improvements in pain and functional limitations were not significant. Overall, collagen appears beneficial for stiffness and the overall experience of knee pain.
7
We investigated how daily collagen peptide (CP) supplementation impacts knee pain and overall function in healthy, active middle-aged adults. In a well-structured double-blind trial, participants were given either a placebo or 10 to 20 grams of CP daily over 6 to 9 months.
The results revealed that 10 grams of CP significantly improved daily activities and pain levels, particularly in those who exercised frequently. Additionally, mental and physical health scores saw positive changes with consistent CP intake. This suggests that collagen supplements can be beneficial for managing knee pain and enhancing quality of life in active adults.
The results revealed that 10 grams of CP significantly improved daily activities and pain levels, particularly in those who exercised frequently. Additionally, mental and physical health scores saw positive changes with consistent CP intake. This suggests that collagen supplements can be beneficial for managing knee pain and enhancing quality of life in active adults.
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
8
This clinical study aimed to evaluate how collagen supplements might ease knee pain related to osteoarthritis.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
References
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2025;26:17. doi:10.1186/s12891-024-08244-w
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. doi:10.52312/jdrs.2025.1965
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. doi:10.1080/19390211.2023.2284982
- Thomas DT, Prabhakar AJ, Eapen C, Patel VD, Palaniswamy V, et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023;20. doi:10.3390/ijerph20237088
- van Dam L, Terink R, Mensink M, de Vos RJ, Zwerver J. The JUMPFOOD study: additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper's knee) in athletes-study protocol for a double-blind randomized controlled trial. Trials. 2023;24:768. doi:10.1186/s13063-023-07783-2
- Yves H, Herman J, Uebelhoer M, Wauquier F, Boutin-Wittrant L, et al. Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation. BMC Musculoskelet Disord. 2023;24:748. doi:10.1186/s12891-023-06800-4
- Chen NF, Lin YY, Yao ZK, Tseng CC, Liu YW, et al. Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats. Nutrients. 2023;15. doi:10.3390/nu15163589
- Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20:2243252. doi:10.1080/15502783.2023.2243252
- Kwon SB, Chinta G, Kundimi S, Kim S, Cho YD, et al. A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats. J Am Nutr Assoc. 2024;43:48. doi:10.1080/27697061.2023.2209880
- Chen CC, Chang SS, Chang CH, Hu CC, Nakao Y, et al. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. Nutr J. 2023;22:17. doi:10.1186/s12937-023-00837-w
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. doi:10.17116/kurort20229904120
- Mohammed A, He S. A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients. 2021;13. doi:10.3390/nu13072454
- Lee HS, Oh KJ, Moon YW, In Y, Lee HJ, et al. Intra-articular Injection of Type I Atelocollagen to Alleviate Knee Pain: A Double-Blind, Randomized Controlled Trial. Cartilage. 2021;13:342S. doi:10.1177/1947603519865304
- García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43:531. doi:10.1007/s00264-018-4211-5
- Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52:167. doi:10.1136/bjsports-2016-097333
- Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017;42:588. doi:10.1139/apnm-2016-0390
- Dima A, Dragosloveanu M, Romila AR, Cristea A, Marinică G, et al. Can Hyaluronic Acid Combined with Chondroitin Sulfate in Viscosupplementation of Knee Osteoarthritis Improve Pain Symptoms and Mobility?. Biomolecules. 2024;14. doi:10.3390/biom14070832
- Ostojic M, Hakam HT, Lovrekovic B, Ramadanov N, Prill R. Treatment of anterior knee pain due to chondromalacia patellae with platelet-rich plasma and hyaluronic acid in young and middle-aged adults, a cohort study. Arch Orthop Trauma Surg. 2024;144:3969. doi:10.1007/s00402-024-05363-w
- Safali S, Ertaş ES, Özdemir A, Cataklı D. Evaluation of single and multiple hyaluronic acid injections at different concentrations with high molecular weight in the treatment of knee osteoarthritis. BMC Musculoskelet Disord. 2024;25:164. doi:10.1186/s12891-024-07200-y
- Li D, Hang R, Meng L, Zhao Z, Zhao C, et al. Co-treatment with Oral Duloxetine and Intraarticular Injection of Corticosteroid plus Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis. Pain Physician. 2024;27:E45.
- Rodriguez-Merchan EC. The role of intraarticular injections of hyaluronic acid in joint pain relief in hemophilic arthropathy. Expert Rev Hematol. 2023;16:811. doi:10.1080/17474086.2023.2271660
- Hill WS, Dohnalek MH, Ha Y, Kim SJ, Jung JC, et al. A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Efficacy and Safety of a Krill Oil, Astaxanthin, and Oral Hyaluronic Acid Complex on Joint Health in People with Mild Osteoarthritis. Nutrients. 2023;15. doi:10.3390/nu15173769
- Colombini A, Doro G, Ragni E, Forte L, de Girolamo L, et al. Treatment with CR500® improves algofunctional scores in patients with knee osteoarthritis: a post-market confirmatory interventional, single arm clinical investigation. BMC Musculoskelet Disord. 2023;24:647. doi:10.1186/s12891-023-06754-7
- Kim JG, Kim KI, Park KB, Park YG, Bae JH, et al. Safety and effectiveness of intra-articular injection of a highly cross-linked hyaluronic acid, LBSA0103 (Synovian): Results from a post-marketing surveillance study in South Korea. PLoS One. 2023;18:e0287222. doi:10.1371/journal.pone.0287222
- Ferkel E, Manjoo A, Martins D, Bhandari M, Sethi P, et al. Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties. Cartilage. 2023;14:424. doi:10.1177/19476035231154530
- Sconza C, Di Matteo B, Queirazza P, Dina A, Amenta R, et al. Ozone Therapy versus Hyaluronic Acid Injections for Pain Relief in Patients with Knee Osteoarthritis: Preliminary Findings on Molecular and Clinical Outcomes from a Randomized Controlled Trial. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108788
- Saviola G, Da Campo G, Bianchini MC, Abdi-Ali L, Comini L, et al. Intra-articular clodronate in patients with knee osteoarthritis non-responder to intra-articular hyaluronic acid - a case report series of 9 patients with 8-month follow-up. Clin Ter. 2023;174:245. doi:10.7417/CT.2023.2528
- Qu Z, Koga H, Tsuji K, Tang G, Yang Y, et al. Hyaluronic acid sheet transplantation attenuates infrapatellar fat pad fibrosis and pain in a rat arthritis model. J Orthop Res. 2023;41:2442. doi:10.1002/jor.25580
- Küçükakkaş O, Aydin T, Yurdakul OV. Evaluation of the effect of intra-articular platelet-rich plasma and hyaluronic acid injections on femoral cartilage thickness in chronic knee osteoarthritis. Acta Orthop Belg. 2022;88:811. doi:10.52628/88.4.10243
- Mao B, Pan Y, Zhang Z, Yu Z, Li J, et al. Efficacy and Safety of Hyaluronic Acid Intra-articular Injection after Arthroscopic Knee Surgery: A Systematic Review and Meta-analysis. Orthop Surg. 2023;15:16. doi:10.1111/os.13602
- Arai T, Suzuki-Narita M, Takeuchi J, Tajiri I, Inage K, et al. Analgesic effects and arthritic changes following intra-articular injection of diclofenac etalhyaluronate in a rat knee osteoarthritis model. BMC Musculoskelet Disord. 2022;23:960. doi:10.1186/s12891-022-05937-y
